Olivier Giroud, Theo Hernandez and Rafael Leao are back in the Milan starting XI against Giacomo Bonaventura’s Fiorentina.
It kicks off at San Siro at 17.00 GMT.
With Napoli beating Udinese 3-2, the Rossoneri need a victory to stop the gap at the top extending beyond eight points going into the long break for the World Cup.
They were held to a stalemate by Cremonese midweek, but the team is much changed, with Giroud and Theo Hernandez back from suspension, while Leao returns after he was rested.
However, Junior Messias joins the absentee list with Mike Maignan, Davide Calabria, Alexis Saelemaekers, Zlatan Ibrahimovic and Alessandro Florenzi.
Fiorentina have found their form after a shaky start, putting together three consecutive Serie A victories, extended to five including the Conference League.
Nico Gonzalez, Riccardo Sottil and Gaetano Castrovilli are out of action, with Arthur Cabral chosen rather than Luka Jovic to lead the attack.
It’s a return to San Siro for ex-Milan midfielder Bonaventura.
Milan: Tatarusanu; Kalulu, Thiaw, Tomori, Theo Hernandez; Bennacer, Tonali; Brahim Diaz, Krunic, Leao; Giroud
Fiorentina: Terracciano; Dodo, Milenkovic, Igor, Biraghi; Amrabat, Mandragora; Ikone, Bonaventura, Saponara; Cabral