Juventus look to Federico Chiesa and the returning Dusan Vlahovic against Mateo Retegui, Vitinha and Albert Gudmundsson of Genoa.
It kicks off at the Allianz Juventus Stadium in Turin at 11.30 GMT.
The Bianconeri slipped down into third place last week following defeat to Napoli and a draw with Atalanta, leapfrogged by Milan.
Arkadiusz Milik and Carlos Alcaraz joined the injury list with muscular issues, but Adrien Rabiot is available again and Vlahovic returns from suspension.
Genoa already held Juve to a draw back in December and are comfortably mid-table, despite back-to-back defeats against Inter and Monza.
Stefano Sabelli sits out a ban, with Aaron Martin and Alan Matturro injured.
Retegui and Gudmundsson as always lead the attack, though Ruslan Malinovskyi is struggling with flu symptoms, so Vitinha gets his first start in a very forward-thinking formation.
Juventus: Szczesny; Gatti, Bremer, Danilo; Cambiaso, McKennie, Locatelli, Miretti, Kostic; Chiesa, Vlahovic
Genoa: Martinez; De Winter, Bani, Vasquez; Spence, Frendrup, Badelj, Messias; Gudmundsson, Vitinha; Retegui
Player statistic
| Danilo |  |
39' |
| Andrea Cambiaso | |
58' | ||
| 65' | |
Vitinha | ||
| Dusan Vlahovic | |
90+2' | ||
| Dusan Vlahovic |  |
90+3' |
Match statistic
