Leaders Milan have Alessio Romagnoli back and Theo Hernandez suspended as they host giant-killers Empoli and their old striker Patrick Cutrone.
It kicks off at San Siro at 19.45 GMT.
You can follow all the build-up and action as it happens on the LIVEBLOG.
Serie A Wk29 Liveblog: Including Sampdoria-Juventus and Milan-Empoli
The Rossoneri are sole leaders after their crucial victory away to Napoli and confidence is sky high.
Theo Hernandez sits out a ban, replaced on the left by Alessandro Florenzi, while Romagnoli returns in defence and Olivier Giroud has shaken off a knock.
Zlatan Ibrahimovic made his comeback as a late substitute against Napoli and should feature here in the second half.
Empoli are giant-killers, already winning away to Juventus, Sassuolo and Napoli this season, but they’ve also badly gone off the boil with only six draws from their last 11 Serie A games.
The campaign is already over for Riccardo Marchizza and Nicolas Haas, while ex-Milan striker Patrick Cutrone is left on the bench.
Andrea Pinamonti is in far better form with nine Serie A goals this season, supported by Liam Henderson and Nedim Bajrami.
Milan: Maignan; Calabria, Kalulu, Tomori, Florenzi; Tonali, Bennacer; Messias, Kessie, Leao; Giroud
Empoli: Vicario; Cacace, S Romagnoli, Luperto, Fiamozzi; Bandinelli, Asllani, Zurkowski; Henderson, Bajrami; Pinamonti