Week 29 opens today at 14.00 GMT with two matches that have strong repercussions for the relegation battle.
Rock bottom Salernitana host a Sassuolo side hoping to challenge for a place in Europe, while Spezia-Cagliari is a real head-to-head on the cusp of the drop zone, as only one point separates the teams.
At 17.00 GMT, Juventus aim to keep their winning streak going away to Sampdoria and are not entirely out of the Scudetto race yet.
Check the stats from Sampdoria-Juventus on the Match Centre.
Leaders Milan take to the field at 19.45 GMT by hosting giant-killers Empoli, who have already won away to Juve and Napoli.
You can keep track of the details of Milan-Empoli with the Match Centre.