The Bianconeri rested Dusan Vlahovic for the first time since he joined in January, but had Federico Bernardeschi suspended, Paulo Dybala, Denis Zakaria, Weston McKennie, Giorgio Chiellini, Leonardo Bonucci, Federico Chiesa and Kaio Jorge injured. Samp were coming off back-to-back defeats with Nicola Murru suspended, Manolo Gabbiadini and Mikkel Damsgaard out for the season, but Stefano Sensi and Morten Thorsby returned.
Szczesny was again called into action at the base of the near post by Stefano Sensi, but again Juve were able to double their lead without having a shot on target. Omar Colley bundled into the back of Kean for a penalty, which Alvaro Morata converted.
After the restart, Yoshida’s diving header went wide from a corner, as did an impressive Francesco Caputo volley, while substitute Vlahovic tested Wladimiro Falcome at the near post.
Sampdoria were awarded a penalty for Adrien Rabiot’s handling offence just inside the box and Candreva stepped up, but saw his spot-kick well saved by a trailing Szczesny hand.
The Blucerchiati did eventually get a goal back with some luck, as Abdelhamid Sabiri’s free kick took a huge deflection off Morata and looped over the helpless Szczesny.
Morten Thorsby hit the side-netting as Samp searched desperately for an equaliser, but instead Juve added a third with Morata’s hopeful back-post header on a Manuel Locatelli cross that squirmed in off Falcone’s leg.
Sampdoria 1-3 Juventus
Yoshida og 23 (J), Morata pen 34, 88 (J), Sabiri 84 (S)
Saved penalty: Candreva 74 (S)