Fiorentina look to Luka Jovic and Nico Gonzalez, while Lecce again start Samuel Umtiti with impressive forward Lameck Banda in this head-to-head for position.
It kicks off at the Stadio Via del Mare at 19.45 UK time (18.45 GMT).
There are only two points between these teams going into the match, so a win would allow Lecce to leapfrog into joint 11th place with Salernitana and Monza.
The Viola have done well enough in the Conference League, beating Hearts 5-1 on Thursday, but lost their last two Serie A games without scoring a single goal.
Sofyan Amrabat is suspended, with Riccardo Sottil and Gaetano Castrovilli still injured.
Lecce only narrowly lost 2-1 to Roma last week when down to 10 men, ending a run of five points from three rounds.
Morten Hjulmand sits out a ban following that dismissal, but Barcelona-owned Umtiti starts in defence.
Lecce: Falcone; Pongracic, Baschirotto, Umtiti, Gallo; Gonzalez, Blin, Askildsen; Strefezza, Ceesay, Banda
Fiorentina: Terracciano; Dodo, Martinez-Quarta, Igor, Biraghi; Bonaventura, Mandragora, Barak; Gonzalez, Jovic, Kouame