Milan must do without Theo Hernandez, as Olivier Giroud and Rafael Leao lead the way with Sergino Dest against a Lazio side with Felipe Anderson and Pedro filling in for Ciro Immobile.
It kicks off at the Stadio Olimpico in Rome at 19.45 GMT.
You can follow all the build-up and action as it happens on the LIVEBLOG.
This is the final game in the first half of the 2022-23 Serie A season and from the next round there will be semi-automatic offside technology.
Both sides are missing key players for this head-to-head for Champions League places, as Theo Hernandez joined Mike Maignan, Fode Ballo-Toure, Alessandro Florenzi and Zlatan Ibrahimovic on the treatment table.
Rade Krunic is back on the bench, with Dest stepping in for Theo Hernandez at left-back.
Once again, Brahim Diaz and Junior Messias are preferred to Charles De Ketelaere and Alexis Saelemaekers, but Pierre Kalulu returns for Simon Kjaer.
Lazio are still without star striker and captain Immobile, so Felipe Anderson is the False 9 flanked by Pedro and Mattia Zaccagni.
Manuel Lazzari is back from his ban and it’s a special game for former Milan defender Alessio Romagnoli, while Sergej Milinkovic-Savic and Luis Alberto pull the midfield strings.
A last-gasp 2-1 win here in April 2022 proved a pivotal moment in the Scudetto race for Stefano Pioli’s men, sealed by Sandro Tonali deep into stoppages.
Lazio: Provedel; Hysaj, Casale, Romagnoli, Marusic; Milinkovic-Savic, Cataldi, Luis Alberto; Pedro, Felipe Anderson, Zaccagni
Milan: Tatarusanu; Calabria, Kalulu, Tomori, Dest; Tonali, Bennacer; Messias, Brahim Diaz, Leao; Giroud