Edin Dzeko and Lautaro Martinez try to revitalise Inter, as they face Marko Arnautovic’s Bologna, coached by Treble winner Thiago Motta.
It kicks off at San Siro at 19.45 GMT.
The Nerazzurri need to focus on climbing back up the table after their disappointing 2-0 defeat to a decimated Juventus at the weekend.
That was a painful Derby d’Italia loss and increased the pressure on Simone Inzaghi.
Romelu Lukaku is joined by Matteo Darmian on the treatment table, but Alessandro Bastoni returns after suffering from flu symptoms.
Lautaro Martinez is not rested ahead of this weekend’s showdown with Atalanta, so the usual pairing with Dzeko continues.
Bologna have won three on the bounce to revitalise their campaign under new coach Thiago Motta, who was part of Inter’s Treble-winning squad in 2010.
Kevin Bonifazi is the only injury absentee, with Marko Arnautovic continuing his bid to be crowned Serie A Capocannoniere.
Both Arnautovic and Gary Medel are former Inter players, while Riccardo Orsolini gets the nod after impressing off the bench against Torino.
Inter: Onana; Skriniar, Acerbi, Bastoni; Dumfries, Barella, Calhanoglu, Mkhitaryan, Dimarco; Lautaro Martinez, Dzeko
Bologna: Skorupski; Posch, Soumaoro, Lucumì, Lykogiannis; Schouten, Medel; Orsolini, Ferguson, Barrow; Arnautovic