Atalanta trust Teun Koopmeiners and Duvan Zapata to break down a Roma side without Chris Smalling and Gini Wijnaldum, as Ola Solbakken supports Tammy Abraham.
It kicks off at the Gewiss Stadium in Bergamo at 19.45 UK time (18.45 GMT).
You can follow all the build-up and action as it happens on the LIVEBLOG.
This is a potentially crucial result for the Champions League places, as a win could push La Dea back in contention and allow Milan to catch Roma in fourth place.
However, a Giallorossi victory would let them equal Juventus in third and close further on second-placed rivals Lazio.
Atalanta are coming off a draw away to Fiorentina and suffered a shock 2-0 home defeat to Bologna in their last Bergamo outing, so confidence is not high.
Ademola Lookman, Hans Hateboer and Matteo Ruggeri are still injured, with Mario Pasalic not only back to full fitness, but also starting in a new 3-4-2-1 formation behind Duvan Zapata.
Once again, Juan Musso is dropped in favour of Marco Sportiello, but it’s the bench for Rasmus Hojlund.
Roma paid a price for their Europa League extra time quarter-final victory over Feyenoord on Thursday, losing both Smalling and Wijnaldum for several weeks.
Rick Karsdorp was already absent, with Paulo Dybala again not risked from the start.
Abraham returns to the line-up with Solbakken and Lorenzo Pellegrini in support.
Atalanta: Sportiello; Toloi, Djimsiti, Scalvini; Zappacosta, De Roon, Ederson, Maehle; Koopmeiners, Pasalic; Duvan Zapata
Roma: Rui Patricio; Mancini, Ibanez, Llorente; Celik, Bove, Cristante, Zalewski; Solbakken, Pellegrini; Abraham
Player statistic
| Marten de Roon |  |
30' | ||
| Mario Pasalic (Assist: Duván Zapata) |
 |
39' |
| 60' | |
Ola Solbakken | ||
| Rafael Tolói | |
74' | ||
| 83' | |
Lorenzo Pellegrini (Assist: Diego Llorente) | ||
| Teun Koopmeiners | |
84' | ||
| José Luis Palomino | |
86' | ||
| Teun Koopmeiners | |
90+5' |
Match statistic
