Juventus are expected to rotate in defence again, with Alvaro Morata returning to partner Cristiano Ronaldo, while Roma have to reshuffle amid absentees.
It kicks off at 17.00 GMT, click here for a match preview.
The Bianconeri have Rodrigo Bentancur suspended and Paulo Dybala injured, but coach Andrea Pirlo enacts some squad rotation between Coppa Italia semi-final ties with Inter.
Juventus are expected to rotate in defence again, with Alvaro Morata returning to partner Cristiano Ronaldo, while Roma have to reshuffle amid absentees.
It kicks off at 17.00 GMT, click here for a match preview.
The Bianconeri have Rodrigo Bentancur suspended and Paulo Dybala injured, but coach Andrea Pirlo enacts some squad rotation between Coppa Italia semi-final ties with Inter.
That means Matthijs de Ligt should be rested in favour of Giorgio Chiellini, while Federico Chiesa returns on the left flank supporting Morata and Ronaldo.
Roma’s problems are well-publicised, as Edin Dzeko is back in the squad following his row with coach Paulo Fonseca, but should only be on the bench.
He has been stripped of the captaincy, although replacement Lorenzo Pellegrini is suspended for this game too, so Bryan Cristante takes over the armband and the midfield role.
Chris Smalling, Pedro and Nicolò Zaniolo injured, with Stephan El Shaarawy and Bryan Reynolds only just arriving in the January transfer window.
It is therefore likely to be a more traditional 3-5-2 formation than the usual 3-4-2-1, with Henrikh Mkhitaryan playing closer support to Borja Mayoral.
Pau Lopez seems to have now become first choice in goal rather than Antonio Mirante.
Juventus: Szczesny; Bonucci, Chiellini, Danilo; Cuadrado, McKennie, Arthur, Rabiot, Chiesa; Morata, Ronaldo
Roma: Pau Lopez; Mancini, Ibanez, Kumbulla; Karsdorp, Villar, Cristante, Veretout, Spinazzola; Mkhitaryan, Borja Mayoral
Ref: Orsato