Victor Osimhen, Piotr Zielinski and Lorenzo Insigne face off against Romelu Lukaku, Christian Eriksen and Lautaro Martinez, as Napoli could go catch Juventus in fourth place if they beat leaders Inter.
It kicks off at the Stadio Diego Armando Maradona at 19.45 UK time (18.45 GMT).
Victor Osimhen, Piotr Zielinski and Lorenzo Insigne face off against Romelu Lukaku, Christian Eriksen and Lautaro Martinez, as Napoli could go catch Juventus in fourth place if they beat leaders Inter.
It kicks off at the Stadio Diego Armando Maradona at 19.45 UK time (18.45 GMT).
Gennaro Gattuso is trying to claw his way back into the top four, but Hirving Lozano is suspended, with David Ospina and Faouzi Ghoulam injured.
Alex Meret therefore starts in goal, but the big change is Osimhen chosen to lead the line and Dries Mertens sent to the bench.
Matteo Politano faces his old club, with Piotr Zielinski and Lorenzo Insigne in support.
Napoli will wear special edition jerseys that were designed by fashionista Marcelo Burlon County of Milan.
Inter are running away with the Scudetto and seeking their 12th consecutive Serie A victory, even though many of the recent results were only won by one-goal margins.
Arturo Vidal and Aleksandar Kolarov remain on the treatment table, but Antonio Conte rarely rotates his squad anyway.
It’s the usual first choice XI, with Nicolò Barella returning from suspension to the midfield with Christian Eriksen and Marcelo Brozovic, supporting Romelu Lukaku and Lautaro Martinez.
Inter have won each of their last three Serie A games played against Napoli, home and away, but haven’t made it four since 2000.
Napoli: Meret; Di Lorenzo, Koulibaly, Manolas, Mario Rui; Fabian Ruiz, Demme; Politano, Zielinski, L Insigne; Osimhen
Napoli bench: Contini, Idasiak, Zedadka, Bakayoko, Elmas, Mertens, Maksimovic, Hysaj, Rrahmani, Petagna, Cioffi, Lobotka
Inter: Handanovic; Skriniar, De Vrij, A Bastoni; Hakimi, Barella, Brozovic, Eriksen, Darmian; Lukaku, Lautaro Martinez
Inter bench: Padelli, Radu, Gagliardini, Alexis Sanchez, Vecino, Sensi, Ranocchia, Perisic, Young, D’Ambrosio, Pinamonti
Ref: Doveri