Juventus have Claudio Marchisio and Giorgio Chiellini back against a revitalised Sampdoria, plus a new 4-3-3 approach.
It kicks off at 19.45 UK time (18.45 GMT), follow the build-up and action to all EIGHT Serie A games on the LIVEBLOG.
The Bianconeri are still top of the table despite a surprise defeat to Milan, but have not been performing anywhere near their potential.
Juventus have Claudio Marchisio and Giorgio Chiellini back against a revitalised Sampdoria, plus a new 4-3-3 approach.
It kicks off at 19.45 UK time (18.45 GMT), follow the build-up and action to all EIGHT Serie A games on the LIVEBLOG.
The Bianconeri are still top of the table despite a surprise defeat to Milan, but have not been performing anywhere near their potential.
The gap is now just two points and with Napoli coming up at the weekend, there’s no more margin for error.
Paulo Dybala and Marko Pjaca are out injured for at least a couple of weeks, so the front two has to be Gonzalo Higuain and Mario Mandzukic.
There is always 16-year-old striking sensation Moise Kean on the bench ready to make his Serie A debut in the second half.
The big news is the return of Marchisio, his first appearance since rupturing the anterior cruciate ligament in his knee back in April, and he’s thrown in from the start.
Chiellini also returns from a lay-off, while Gigi Buffon is rested in favour of Norberto Neto.
It’s a 4-3-3 system with Juan Cuadrado completing the unusual trident.
Sampdoria are revitalised after beating city rivals Genoa in the Derby della Lanterna and want to ride that wave of enthusiasm.
There are several changes to the side that won that intense encounter on Saturday, bringing in Ante Budimir, Luca Cigarini, Dennis Praet and Ricky Alvarez.
Emiliano Viviano, Daniel Pavlovic and Carlos Carbonero are still sidelined.
In the last 20 years, Sampdoria have only won twice away to Juventus in February 2005 and January 2013.
Last season, the Blucerchiati were hammered 5-0 in this fixture.
Juventus: Neto; Dani Alves, Bonucci, Chiellini, Evra; Pjanic, Khedira, Marchisio, Cuadrado, Mandzukic, Higuain
Sampdoria: Puggioni; Sala, Silvestre, Skriniar, Regini; Barreto, Cigarini, Praet; Alvarez; Budimir, Schick