Napoli are forced to use Dries Mertens as a False 9 because there are no available centre-forwards against Empoli.
It kicks off at 19.45 UK time (18.45 GMT), follow the build-up and action from all eight Serie A games on the LIVEBLOG.
Arkadiusz Milik has not been suitably replaced after his ruptured ACL and Manolo Gabbiadini first floundered, then got himself sent off for a reaction foul against Crotone with two-match ban.
Napoli are forced to use Dries Mertens as a False 9 because there are no available centre-forwards against Empoli.
It kicks off at 19.45 UK time (18.45 GMT), follow the build-up and action from all eight Serie A games on the LIVEBLOG.
Arkadiusz Milik has not been suitably replaced after his ruptured ACL and Manolo Gabbiadini first floundered, then got himself sent off for a reaction foul against Crotone with two-match ban.
Maurizio Sarri is forced to use Mertens as a False 9 flanked by Lorenzo Insigne and Jose Callejon, as there aren’t really any other options.
Raul Albiol is also still missing in the centre of defence, this time replaced by Vlad Chiriches, while Christian Maggio starts and Marek Hamsik is rested.
Empoli only have to do without Vincent Laurini, but this is a special game for Coach Giovanni Martusciello – who was Sarri’s assistant manager at the Stadio Castellani.
Riccardo Saponara, Manuel Pucciarelli and Levan Mchedlidze lead the trident attack and hope to break Empoli’s six-game goal drought.
The Tuscans had done well in this fixture with four wins and as many draws from December 1999 until capitulating in spectacular fashion last season by a 5-1 scoreline.
Pepe Reina is making his 100th official appearance in the Napoli jersey.
Napoli: Reina; Maggio, Chiriches, Koulibaly, Ghoulam; Allan, Jorginho, Zielinski; Callejon, Mertens, L Insigne
Empoli: Skorupski; Veseli, Bellusci, Costa, Dimarco; Krunic, Diousse, Buchel; Saponara; Pucciarelli, Mchedlidze