It’s a fascinating Derby d’Italia for the Scudetto, with Romelu Lukaku and Lautaro Martinez against Cristiano Ronaldo and Alvaro Morata.
It kicks off at San Siro at 19.45 GMT.
You can follow all the build-up and action as it happens on the LIVEBLOG.
With Roma losing to Lazio, this has become a head-to-head for second place and the chance to chase down leaders Milan.
It’s a fascinating Derby d’Italia for the Scudetto, with Romelu Lukaku and Lautaro Martinez against Cristiano Ronaldo and Alvaro Morata.
It kicks off at San Siro at 19.45 GMT.
You can follow all the build-up and action as it happens on the LIVEBLOG.
With Roma losing to Lazio, this has become a head-to-head for second place and the chance to chase down leaders Milan.
Andrea Pirlo faces his former coach for the first time, as Antonio Conte tries to end the nine-year winning streak that he started in Turin.
It’ll require a sea change in statistics, because Conte has lost all three Serie A matches against Juve as a coach.
Danilo D’Ambrosio is the only absentee for Inter, along with long-term cases Matias Vecino and Andrea Pinamonti.
Romelu Lukaku and Lautaro Martinez are always the first-choice front two, with Arturo Vidal getting the midfield nod ahead of Roberto Gagliardini.
Marcelo Brozovic and Nicolò Barella complete the midfield, with Achraf Hakimi’s pace a major threat.
Juve are still without Matthijs de Ligt, Alex Sandro and Juan Cuadrado, who all tested positive for COVID-19.
Paulo Dybala is also out with a knee ligament injury, so Morata is the inevitable partner for Capocannoniere Cristiano Ronaldo.
Federico Chiesa is back in action after a knock, as is Aaron Ramsey, with Gianluca Frabotta given a chance.
Weston McKennie is only fit enough for the bench, but Giorgio Chiellini is back in the starting XI.
Both teams were forced to play 120 minutes in the Coppa Italia on Wednesday, as Inter beat Fiorentina 2-1 in extra time, while Juve eventually saw off Genoa 3-2.
Inter: Handanovic; Skriniar, De Vrij, Bastoni; Hakimi, Barella, Brozovic, Vidal, Young; R Lukaku, Lautaro Martinez
Inter bench: Padelli, Radu, Gagliardini, Alexis Sanchez, Kolarov, Sensi, A Ranocchia, Perisic, Eriksen, Darmian, Pinamonti
Juventus: Szczesny; Danilo, Bonucci, Chiellini, Frabotta; Chiesa, Rabiot, Bentancur, Ramsey; Morata, Ronaldo
Juventus bench: Pinsoglio, Garofani, Buffon, Arthur, McKennie, Demiral, Bernardeschi, Di Pardo, Dragusin, Fagioli, Kulusevski, F Ranocchia
Ref: Doveri