Juventus seem set to give Mattia Perin the gloves, while Federico Chiesa and Paulo Dybala should start against Sassuolo on Wednesday.
The match at the Allianz Stadium kicks off at 17.30 UK time.
Max Allegri rotates against the Neroverdi, expected to make changes from the squad that played Inter at San Siro last time and is prepared to rotate in defence for Serie A Week 10.
Matthijs de Ligt and Mattia De Sciglio should replace Giorgio Chiellini and Alex Sandro, while Chiesa takes the place of Federico Bernardeschi, who struggles with a shoulder problem.
Juan Cuadrado is confirmed on the side, while Arthur Melo and Rodrigo Bentancur should start in the middle.
Up front, Dybala will most likely take place with Alvaro Morata from the first minute.
Alessio Dionis, on the other hand, is only forced to make one change from the line-up in the 3-1 win against Venezia.
Filip Djuricic misses the big game against the Bianconeri and seems set to start with Junior Traore in the attacking trident with Domenico Berardi and Giacomo Raspadori, behind striker Gianluca Sacamacca.
Probable line-ups: Juventus vs. Sassuolo
Juventus (4-4-2): Perin; Danilo, Bonucci, De Ligt, De Sciglio; Cuadrado, Bentancur, Arthur, Chiesa; Dybala, Morata
Sassuolo (4-2-3-1): Consigli; Toljan, Chiriches, Ferrari, Rogerio; Maxime Lopez, Frattesi; Berardi, Raspadori, Traore; Scamacca