Juventus have a 1-0 first leg lead to defend in Lisbon with Federico Chiesa, Angel Di Maria and Dusan Vlahovic, but Sporting CP have already shown they are a force to be reckoned with in the Europa League.
The quarter-final kicks off at the Estadio Alvalade at 20.00 UK time (19.00 GMT).
As the away goals rule no longer applies, any defeat here by a one-goal margin will force extra time.
That automatically puts Juve in third place behind Lazio on 59 points, ahead of Roma, Milan and Inter.
Moise Kean is the only injury absentee, as Adrien Rabiot shakes off a knock to start, while Chiesa starts in place of Filip Kostic in a more attack-minded side with Di Maria and Vlahovic.
Wojciech Szczesny is back in goal for the first time since going off in the first leg in tears, more due to fear than pain, as he felt breathless after colliding with the upright.
Danilo, Fabio Miretti, Bremer and Vlahovic are all one yellow card away from a ban.
Sporting have Manuel Ugarte available again after he missed the first leg through suspension, but Jerry St. Juste, Jovane, Paulinho and Daniel Bragança are still on the treatment table.
Only the extraordinary saves of Szczesny and then Mattia Perin prevented Sporting from scoring in Turin.
Sporting: Adan; Diomande, Coates, Goncalo Inacio; Esgaio, Ugarte, Morita, Nuno Santos; Edwards, Trincao, Pedro Goncalves
Juventus: Szczesny; Danilo, Bremer, Alex Sandro; Cuadrado, Miretti, Locatelli, Rabiot, Chiesa; Di Maria, Vlahovic
Ref: Letexier (FRA)
Player statistic
| 9' |  |
Adrien Rabiot (Assist: Alex Sandro) | ||
| Marcus Edwards |  |
20' | ||
| Manuel Ugarte |  |
24' |
| 83' | |
Federico Gatti | ||
| 89' | |
Paul Pogba | ||
| Marcus Edwards | |
90+3' |
Match statistic
