Roma have it all to do, as they must overturn a 1-0 deficit against Feyenoord in the Europa League quarter-final with Paulo Dybala and Tammy Abraham on the bench.
It kicks off at the Stadio Olimpico at 20.00 UK time (19.00 GMT).
The Giallorossi were beaten 1-0 in Rotterdam at the end of a very even match and were left to rue Lorenzo Pellegrini firing a penalty onto the upright.
Both Dybala and Abraham went off early in the first leg with injuries, so are on the bench after recovering from a muscular issue and dislocated shoulder respectively.
Andrea Belotti leads the attack with Gini Wijnaldum and Lorenzo Pellegrini in support.
Rick Karsdorp is the only absentee for Jose Mourinho’s men, who have a stadium packed to the rafters with no Dutch supporters allowed due to security concerns.
Feyenoord are out for revenge after losing the Conference League Final to Roma last season and were already beaten in this stadium 4-2 by Lazio in the Europa League group phase, despite eventually pushing the Biancocelesti out.
Mats Wieffer is in the line-up despite an ankle problem and he scored the winner in Rotterdam, but Quinten Timber, Mimeirhel Benita and Patrik Walemark are out.
While Roma are unbeaten at home against Dutch opponents, they drew four of those five games, winning only in 1969 against PSV Eindhoven for the Cup Winners’ Cup.
Roma: Rui Patricio; Mancini, Llorente, Smalling; Zalewski, Cristante, Wijnaldum, Matic, Spinazzola; Pellegrini; Belotti
Feyenoord: Bijlow; Geertruida, Trauner, Hancko, Hartman; Wieffer, S Szymanski, Kokcu; Jahanbakhsh, Gimenez, Idrissi
Ref: Taylor (ENG)
Player statistic
12' | Quilindschy Hartman | |||
18' | Mats Wieffer | |||
Diego Llorente | 34' | |||
39' | Santiago Giménez |
Leonardo Spinazzola (Assist: Bryan Cristante) |
60' | |||
80' | Igor Paixão (Assist: Sebastian Szymanski) | |||
Paulo Dybala (Assist: Lorenzo Pellegrini) |
89' |
Stephan El Shaarawy (Assist: Tammy Abraham) |
101' | |||
Paulo Dybala | 108' | |||
Lorenzo Pellegrini | 109' | |||
Tammy Abraham | 111' | |||
Rui Patrício | 118' | |||
120' | Santiago Giménez |