Juventus finally rest Dusan Vlahovic, so Moise Kean partners Alvaro Morata for this trip to Fabio Quagliarella and Stefano Sensi’s Sampdoria.
It kicks off at the Stadio Luigi Ferraris, also known as Marassi, at 17.00 GMT.
You can follow all the build-up and action as it happens on the LIVEBLOG.
The Bianconeri are unbeaten in 14 Serie A rounds and squeezed past Spezia 1-0 last week, but the injury crisis continues to bite.
Paulo Dybala, Denis Zakaria, Weston McKennie, Giorgio Chiellini, Leonardo Bonucci, Federico Chiesa and Kaio Jorge are still out of action, with Federico Bernardeschi suspended.
Vlahovic is finally given a rest for the first time since joining Juve in January, as he gears up for the Champions League clash with Villarreal.
Max Allegri gives Moise Kean the nod with Alvaro Morata instead.
Sampdoria are coming off back-to-back defeats to Atalanta and Udinese.
Nicola Murru sits out a ban, but Stefano Sensi and Morten Thorsby are available again.
Manolo Gabbiadini and Mikkel Damsgaard are out for the rest of the season.
Veteran front pair Quagliarella and Ciccio Caputo lead the way, with Antonio Candreva on the right.
Sampdoria: Falcone; Bereszynski, Yoshida, Colley, Augello; Candreva, Rincon, Thorsby; Sensi; Caputo, Quagliarella
Juventus: Szczesny; Danilo, De Ligt, Rugani, Pellegrini; Locatelli, Arthur, Rabiot; Cuadrado, Kean, Morata