Roma look to Lorenzo Pellegrini, Tammy Abraham while benching Nicolò Zaniolo, as Lazio bring in Pedro against his former teammates with Ciro Immobile and Felipe Anderson.
The Derby della Capitale kicks off at the Stadio Olimpico at 17.00 GMT.
Serie A Liveblog inc Juve-Salernitana, Roma-Lazio, Bologna-Atalanta
Jose Mourinho is missing only Leonardo Spinazzola, as Henrikh Mkhitaryan and Marash Kumbulla return from suspension, while Pellegrini has recovered from tonsillitis.
Abraham leads the way, but Zaniolo is dropped to the bench following poor recent form, also fatigued by Thursday’s Conference League draw with Vitesse.
Lazio have Mattia Zaccagni suspended after he was booked for simulation, with Stefan Radu injured.
That means Pedro starts against his former teammates, having been pushed out essentially for free over the summer.
Immobile and Felipe Anderson are supported by Sergej Milinkovic-Savic and Luis Alberto.
It’s not just a local derby, but also a head-to-head for European places, as only one point separates them going in.
Lazio won 3-2 earlier this season, giving them back-to-back Serie A victories against their bitter rivals.
However, Roma are unbeaten in eight Serie A rounds.
Roma: Rui Patricio; Mancini, Smalling, Ibanez; Karsdorp, Cristante, Sergio Oliveira, Zalewski; Pellegrini, Mkhitaryan; Abraham
Lazio: Strakosha; Hysaj, Luiz Felipe, Acerbi, Marusic; Milinkovic-Savic, Leiva, Luis Alberto; Felipe Anderson, Immobile, Pedro