Juventus have Manuel Locatelli supporting Moise Kean and Arkadiusz Milik, while Lazio look to Felipe Anderson and Sergej Milinkovic-Savic in this head-to-head for second place.
It kicks off at the Allianz Juventus Stadium in Turin at 19.45 GMT.
Going into this final round of 2022 before the break for the World Cup, Lazio are joint second with Milan on 30 points, followed by Juventus on 28.
Inter already won away to Atalanta to go on 30 points too.
Both sides have serious injury problems to deal with and therefore have to reshuffle their squads.
Juve are missing Dusan Vlahovic, Mattia De Sciglio, Paul Pogba, Kaio Jorge and Samuel Iling-Junior, with Angel Di Maria and Leandro Paredes only fit for the bench.
Alex Sandro also sits out a ban after his red card in the midweek win over Verona.
The good news is that Manuel Locatelli and Juan Cuadrado have shaken off knocks to start, while Federico Chiesa is back on the bench again.
Leonardo Bonucci is once more dropped in favour of Gleison Bremer and Federico Gatti.
Mattia Perin is not even on the bench after suffering from gastroenteritis.
Lazio are missing club legend Ciro Immobile, who suffered a relapse of that thigh strain and is ruled out again, with Mattia Zaccagni, Manuel Lazzari and Patric also on the treatment table.
Luka Romero and Pedro therefore step into the trident attack, with Felipe Anderson as the False 9, supported by Milinkovic-Savic.
Romero turns 18 later this month and scored his debut Serie A goal midweek.
Juventus: Szczesny; Gatti, Bremer, Danilo; Cuadrado, Fagioli, Locatelli, Rabiot, Kostic; Kean, Milik
Lazio: Provedel; Hysaj, Casale, Romagnoli, Marusic; Milinkovic-Savic, Cataldi, Basic; Romero, Felipe Anderson, Pedro