Romelu Lukaku is on the Inter bench after marking his comeback with a goal midweek, as Lautaro Martinez and Edin Dzeko take on Dejan Stankovic’s Sampdoria.
It kicks off at San Siro at 19.45 UK time (18.45 GMT).
The Nerazzurri secured their Champions League qualification this week by beating Viktoria Plzen 4-0, including a goal from Lukaku just four minutes into his comeback from two months out injured.
They are coming off three straight Serie A wins to climb back up the table, despite still missing Marcelo Brozovic with a thigh injury.
There are few changes for Simone Inzaghi, with Hakan Calhanoglu, Henrikh Mkhitaryan and Nicolò Barella again forming the midfield.
It is a special night for Sampdoria coach Dejan Stankovic, who was in the Inter squad that won the Treble in 2010.
So far on the Blucerchiati bench, he has earned a draw with Bologna, lost narrowly at Roma and won 1-0 away to Cremonese to climb off the foot of the table.
Fabio Quagliarella, Harry Winks and Manuel De Luca are out of action.
Inter: Onana; Skriniar, De Vrij, Bastoni; Dumfries, Barella, Calhanoglu, Mkhitaryan, Dimarco; Lautaro Martinez, Dzeko
Sampdoria: Audero; Ferrari, Colley, Amione; Bereszynski, Villar, Djuricic, Leris; Caputo, Gabbiadini