Romelu Lukaku, Marcelo Brozovic and Robin Gosens get rare starts as Inter visit Thiago Motta’s Bologna, who are coming off strong results despite losing Marko Arnautovic.
It kicks off at the Stadio Dall’Ara at 11.30 GMT.
The Scudetto was effectively lost here last season with a 2-1 defeat, aided by goalkeeper Ionut Radu’s howler, so there are still negative memories associated with this fixture.
Napoli already beat Empoli 2-0 on Saturday, so failure to get all three points here would see Inter fall even further behind the leaders.
Fresh from a 1-0 Champions League win over FC Porto, the Nerazzurri are without injured Federico Dimarco, Milan Skriniar and Joaquin Correa.
There is also some rest for Nicolò Barella and Francesco Acerbi, giving Brozovic his first start since before the World Cup.
Bologna are on a strong run of form under coach Thiago Motta, winning four of their last six games, losing only to Monza.
Adama Soumaoro is only available for the bench, but Marko Arnautovic, Joshua Zirkzee and Kevin Bonifazi are on the treatment table.
Bologna: Skorupski; Posch, Sosa, Lucumi, Cambiaso; Domiguez, Schouten; Orsolini, Ferguson, Soriano; Barrow
Inter: Onana; Darmian, De Vrij, Bastoni; Dumfries, Mkhitaryan, Brozovic, Calhanoglu, Gosens; Lukaku, Lautaro Martinez
Player statistic
| 45+1' |  |
Stefan de Vrij |
| 63' | |
Denzel Dumfries | ||
| Riccardo Orsolini (Assist: Jerdy Schouten) |
 |
76' | ||
| Nicolás Domínguez | |
85' |
Match statistic
