Riccardo Calafiori and Matias Vina are injured, while Ebrima Darboe is dropped and Lorenzo Pellegrini must grit his teeth for Roma.
The trip to Venezia is on Sunday at 11.30 GMT and Jose Mourinho is forced to again reshuffle his squad.
Vina, Chris Smalling and Leonardo Spinazzola are still on the treatment table after Thursday’s 2-2 Europa Conference League draw with Bodo/Glimt at the Stadio Olimpico.
Roger Ibanez was used as a left-back against the Norwegians and it is a position again foisted upon him, because alternative Calafiori is also out of action.
Pellegrini missed that match due to a knee inflammation, having played against Milan with heavy strapping, and skipped this morning’s training session.
However, the captain is expected to grit his teeth and play on in Venezia.
There is another exit, as Darboe has been dropped following his disappointing performance against Bodo/Glimt.