Torino are still coping without their injured captain Andrea Belotti, as Lazio are struggling to rotate ahead of the clash on Thursday.
The match kicks off at 17.30 UK time at the Grande Torino.
Belotti has been missing since the second game and is still recovering from the tendon injury, but Torino have won both games without their talisman, beating Salernitana 4-0 and Sassuolo 1-0 in their two last games.
Ivan Juric have some more problems ahead of the tie, as he will be without Dennis Praet and risks not being able to call on Marko Pjaca, the match winner against Sassuolo.
Karol Linetty should complete the attacking trident with Josip Brekalo and Antonio Sanabria, while Juric must wait to see if Izzo and Simone Verdi can play against Lazio.
Maurizio Sarri is still suspended, as his appeal was rejected by the FIGC, and Lazio continue without their coach in the dugout.
The coach doesn’t have too many options to rotate, despite playing their second match in short time and having one eye on the big derby against Roma this weekend.
Manuel Lazzari seems set to start over Adam Marusic at right, while Stefan Radu could replace Elseid Hysaj at left.
Danilo Cataldi scored the equaliser against Cagliari last time and pushes for a start against Torino, while Mattia Zaccagni is out with an injury.
Pedro, Ciro Immobile and Felipe Anderson are expected to start up front for the Biancocelesti tonight.
Probable line-ups
Torino (3-4-2-1): V. Milinkovic-Savic; Djidji, Bremer, Rodriguez; Singo, Pobega, Mandragora, Ola Aina; Linetty, Brekalo; Sanabria
Lazio (4-3-3): Reina; Lazzari, Luiz Felipe, Acerbu, Radu; S. Milinkovic-Savic, Leiva, Luis Alberto; Pedro, Immobile, Felipe Anderson
Why Leiva again and not Basic? Or Cataldi?