Sampdoria could be without Morten Thorsby, while Napoli should arrive with Victor Osimhen, Hirving Lozano, Piotr Zielinski and Lorenzo Insigne in attack.
The match kicks off at 17.30 UK time at the Luigi Ferraris.
Roberto D’Aversa’s men are confident ahead of the clash with faultless Napoli, who are the only team with four wins in four games heading into Serie A Week 5.
Luciano Spalletti’s men aim to continue down the same path and the coach could bench Matteo Politano at Marassi.
Lozano should be ready to start for the Partenopei, while Sampdoria could be without midfielder Thorsby, who has trained individually all week.
Adrien Silva is expected to start in the middle with Albin Ekdal, while Napoli continue to rely on a 4-2-3-1 formation.
Zambo Anguissa seems certain to start with Fabian Ruiz in the middle, while Kostas Manolas and Amir Rrahmani fight for the place next to Kalidou Koulibaly in defence.
Probable line-ups
Sampdoria (4-4-2): Audero; Bereszynski, Yoshida, Colley, Augello; Candreva, Thorsby, Ekdal, Damsgaard; Caputo, Quagliarella
Napoli (4-2-3-1): Ospina; Di Lorenzo, Rrahmani, Koulibaly, Mario Rui; Anguissa, Fabian Ruiz; Lozano, Zielinski, Insigne; Osimhen