Lazio await news from Ciro Immobile and his strike partner, while Roma should risk Kostas Manolas and Daniele De Rossi in the Derby della Capitale.
It kicks off at 19.30 GMT, click here for a match preview.
This is a massive clash of local rivals, but also a tussle for position in the race for Champions League berths, especially after third-place Inter lost to Cagliari on Friday evening.
Lazio await news from Ciro Immobile and his strike partner, while Roma should risk Kostas Manolas and Daniele De Rossi in the Derby della Capitale.
It kicks off at 19.30 GMT, click here for a match preview.
This is a massive clash of local rivals, but also a tussle for position in the race for Champions League berths, especially after third-place Inter lost to Cagliari on Friday evening.
Simone Inzaghi is dealing with injury problems that have ruled out Wallace, Luiz Felipe, Valon Berisha and Jordan Lukaku.
Hitman Immobile is not 100 per cent fit either, but will play through the pain to ensure he doesn’t miss the biggest game of the season.
His partner remains to be seen, as Luis Alberto, Joaquin Correa and Felipe Caicedo are all options, but the Ecuador international is the current front-runner.
Stefan Radu returns after missing the Coppa Italia draw with Milan due to suspension, sending Patric to the bench.
Adam Marusic is the favourite to start wide right of midfield rather than Romulo.
Roma have their own share of problems, as Manolas and De Rossi are carrying knocks, but both are expected to start regardless.
Patrik Schick and Rick Karsdorp returned to the squad following lengthy lay-offs and are set for the bench, with Cengiz Under the only remaining absentee.
It’s expected to be a 4-3-3 formation with Alessandro Florenzi at right-back, Bryan Cristante and Lorenzo Pellegrini flanking captain De Rossi.
This means Nicolò Zaniolo moves up into the trident attack next to Edin Dzeko and Stephan El Shaarawy.
Lazio (probable): Strakosha; Bastos, Acerbi, Radu; Romulo, Parolo, Leiva, Milinkovic, Lulic; Caicedo, Immobile
Roma (probable): Olsen; Florenzi, Manolas, Fazio, Kolarov; Cristante, De Rossi, Pellegrini; Zaniolo, Dzeko, El Shaarawy
Ref: Mazzoleni