Milan are expected to start Andrea Bertolacci, Mario Pasalic and Keisuke Honda against Roma.
It kicks off at 20.00 GMT and both sides are currently locked together in second place.
Follow the build-up and action while giving your views on the LIVEBLOG.
The Giallorossi are without Francesco Totti, Mohamed Salah, Leandro Paredes and Alessandro Florenzi, but Kevin Strootman is available after his two-match ban was revoked.
Milan are expected to start Andrea Bertolacci, Mario Pasalic and Keisuke Honda against Roma.
It kicks off at 20.00 GMT and both sides are currently locked together in second place.
Follow the build-up and action while giving your views on the LIVEBLOG.
The Giallorossi are without Francesco Totti, Mohamed Salah, Leandro Paredes and Alessandro Florenzi, but Kevin Strootman is available after his two-match ban was revoked.
Stephan El Shaarawy is not expected to start against his former club, so Bruno Peres and Emerson Palmieri take wing-back roles supporting Diego Perotti, Radja Nainggolan and Edin Dzeko.
Milan have problems to contend with, as Carlos Bacca and Giacomo Bonaventura joined the absentee list with Davide Calabria, Riccardo Montolivo and suspended Juraj Kucka.
According to the latest reports, Bertolacci will take the midfield spot, making his first appearance since a five-minute spell on August 21.
Pasalic also starts with Manuel Locatelli in a very young middle of the park.
The other change is in the trident attack, where Honda is chosen ahead of M’Baye Niang to partner Gianluca Lapadula and Suso.
Predicted line-ups
Roma: Szczesny; Manolas, Fazio, Rüdiger; Peres, De Rossi, Strootman, Emerson; Nainggolan; Perotti, Dzeko
Roma bench: Alisson, Greco, Vermaelen, Juan Jesus, Mario Rui, Seck, Gerson, Spinozzi, Iturbe, El Shaarawy
Milan: Donnarumma; Abate, Paletta, Romagnoli, De Sciglio; Pasalic, Locatelli, Bertolacci; Suso, Lapadula, Honda
Milan bench: Gabriel, Plizzari, Zapata, Gomez, Ely, Antonelli, Vangioni, Poli, Mati Fernandez, Niang, Luiz Adriano, Sosa