Lazio have two major doubts going into the head-to-head with Milan, while the Rossoneri are likely to rotate once again, despite the setback against Cremonese.
It kicks off at San Siro on Saturday at 14.00 UK time (13.00 GMT).
This is a potentially decisive result in the race for the top four, as Lazio are currently in second, only six points clear of Milan in joint fifth with Atalanta and Roma.
Stefano Pioli is torn between rotating the squad to prepare for Wednesday’s Champions League semi-final against Inter and putting more focus onto securing fourth place and qualification for the tournament next season.
That becomes increasingly pressing after a 1-1 draw with Cremonese saw them slide down the table and another hiccup would be very damaging.
Fikayo Tomori returns after suspension and has shaken off his injury, though Tommaso Pobega and Zlatan Ibrahimovic are still out of action.
It ought to be a practically full-strength XI with Junior Messias stepping in for Brahim Diaz, supporting Rafael Leao and Olivier Giroud.
Lazio have midfield problems, because both Danilo Cataldi and his natural heir Matias Vecino are out with muscular issues, while Luis Alberto is reportedly heading towards the bench.
Mattia Zaccagni is also in doubt, having missed the last two training sessions, and may be replaced by Pedro in the front three.
Probable line-ups
Milan (4-2-3-1): Maignan; Calabria, Kjaer, Tomori, Theo Hernandez; Tonali, Krunic; Brahim Diaz, Bennacer, Leao; Giroud
Lazio (4-3-3): Provedel; Marusic, Casale, Romagnoli, Hysaj; Miliknovic-Savic, Marcos Antonio, Basic; Felipe Anderson, Immobile, Pedro