Roma aim to end 2014 one point adrift of leaders Juventus, but host a Milan side that is pushing for third place.
It kicks off at the Stadio Olimpico at 19.45 GMT, click here for a match preview.
Juve already won their game against Cagliari, so the gap currently stands at four points.
Rudi Garcia and Jose Holebas won their late appeals against suspension and will therefore be taking part in this game, but Miralem Pjanic and Davide Astori are still banned.
Roma aim to end 2014 one point adrift of leaders Juventus, but host a Milan side that is pushing for third place.
It kicks off at the Stadio Olimpico at 19.45 GMT, click here for a match preview.
Juve already won their game against Cagliari, so the gap currently stands at four points.
Rudi Garcia and Jose Holebas won their late appeals against suspension and will therefore be taking part in this game, but Miralem Pjanic and Davide Astori are still banned.
Kostas Manolas returns from injury to bolster the back four with Daniele De Rossi stepping in for Pjanic after being dropped recently.
Gervinho, Francesco Totti and Alessandro Florenzi complete the trident attack following a precious and hard-fought 1-0 win away to Genoa last week.
Florenzi returns to his more traditional attacking role in place of Adem Ljajic, having filled in as a full-back during the recent injury crisis.
Milan are trying to prove they can challenge with the big boys this season under novice Coach Pippo Inzaghi and sent a strong message by beating Napoli 2-0.
A victory at the Olimpico would put them into joint third place with Napoli, pending other results for Genoa, Sampdoria and Lazio.
The injury crisis drags on for the Rossoneri, missing Ignazio Abate, Mattia De Sciglio, Marco van Ginkel, Hachim Mastour and Adil Rami, but Alex returns on the bench.
It’s a very special game for Philippe Mexes and Jeremy Menez, who both started their Serie A careers playing for Roma.
Keisuke Honda and Giacomo Bonaventura complete the attack, as once again flop Fernando Torres is left on the bench.
Milan will wear their all-white away kit.
Roma: De Sanctis; Maicon, Manolas, Yanga-Mbiwa, Holebas; Keita, De Rossi, Nainggolan; Florenzi, Totti, Gervinho
Roma bench: Lobont, Curci, Somma, Cole, Emanuelson, Torosidis, Paredes, Strootman, Ljajic, Iturbe, Borriello, Destro
Milan: Diego Lopez; Bonera, Zapata, Mexes, Armero; Montolivo, De Jong, Poli; Honda, Menez, Bonaventura
Milan bench: Abbiati, Agazzi, Albertazzi, Alex, Zaccardo, Essien, Muntari, Saponara, El Shaarawy, Niang, Pazzini, Torres