Roma look to Gervinho, Seydou Doumbia and Victor Ibarbo as they host a Genoa side on fine form looking for Europe.
It kicks off at 11.30 UK time (10.30 GMT), follow the action as it happens on our LIVEBLOG.
Rudi Garcia’s men appear to have found their feet after a dismal run of results and are still only one point adrift of Lazio in second place.
They also need to look over their shoulders, where Napoli are eager to close in for Champions League qualification.
Roma look to Gervinho, Seydou Doumbia and Victor Ibarbo as they host a Genoa side on fine form looking for Europe.
It kicks off at 11.30 UK time (10.30 GMT), follow the action as it happens on our LIVEBLOG.
Rudi Garcia’s men appear to have found their feet after a dismal run of results and are still only one point adrift of Lazio in second place.
They also need to look over their shoulders, where Napoli are eager to close in for Champions League qualification.
Fresh from a 3-0 drubbing of Sassuolo on Wednesday night, Doumbia finally broke his goal duck with a powerful header.
He starts again with Gervinho and Ibarbo, so Francesco Totti is dropped for the second game in a row.
Douglas Maicon, Leandro Castan and Kevin Strootman are still out of action, while Seydou Keita has a knee problem.
Genoa have Nicolas Andre Burdisso suspended against his former club, plus Diego Perotti, Lorenzo Ariaudo and Giovanni Marchese injured.
Iago Falque has scored four goals in his last five games, but is initially rested, so Diego Laxalt starts along with Milan-owned M’Baye Niang.
History is not on the Grifone’s side, as they have lost their last eight consecutive trips to the Olimpico in all competition.
The last point picked up in this fixture was a draw in January 1994.
Roma: De Sanctis; Florenzi, Manolas, Astori, Torosidis; Pjanic, De Rossi, Nainggolan; Gervinho, Doumbia, Ibarbo
Genoa: Perin; Roncaglia, De Maio, Izzo, Tambe'; Rincon, Bertolacci, Kucka, Laxalt, Niang, Bergdich