Roma look to Stephan El Shaarawy and Daniele De Rossi as they host giant-killers Bologna, hoping to go eight points clear in third.
It kicks off at 19.45 UK time (18.45 GMT), click here for a match preview.
The Giallorossi have the opportunity to consolidate their Champions League preliminary round spot and remain within four points of Napoli in second.
Roma look to Stephan El Shaarawy and Daniele De Rossi as they host giant-killers Bologna, hoping to go eight points clear in third.
It kicks off at 19.45 UK time (18.45 GMT), click here for a match preview.
The Giallorossi have the opportunity to consolidate their Champions League preliminary round spot and remain within four points of Napoli in second.
Radja Nainggolan sits out a ban, completing a difficult week for him after transfer speculation with Chelsea and seeing his house burgled.
This gives De Rossi the chance to step back into the starting XI following back problems.
Mohamed Salah, Diego Perotti and El Shaarawy complete the trident attack, so Edin Dzeko is dropped.
A big surprise is the inclusion of Iago Falque in a midfield role, as he has been largely ignored since Luciano Spalletti took over from Rudi Garcia in January.
Bologna have numerous absentees to deal with and have stuttered recently with just three draws in the last six rounds.
However, Roberto Donadoni’s men do tend to raise their game against the big clubs and are the only side to have stopped Juventus winning in the last 23 Serie A games.
Emanuele Giaccherini is suspended with Mattia Destro, Anthony Mounier, Saphir Taider, Archimede Morleo and Franco Zuculini injured.
Bologna haven’t beaten Roma, home or away, since a 3-2 result at the Olimpico in September 2012. It was a classic Zdenek Zeman performance, as the hosts were 2-0 up after 16 minutes. The Rossoblu have just one victory against the Giallorossi in over a decade.
Roma: Szczesny; Florenzi, Manolas, Rüdiger, Digne; De Rossi, Pjanic, Falque; Salah, Perotti, El Shaarawy
Roma bench: De Sanctis, Castan, Maicon, Torosidis, Zukanovic, Emerson, Keita, Vainqueur, Strootman, Uçan, Totti, Dzeko
Bologna: Mirante; Mbaye, Rossettini, Maietta, Masina; Diawara, Donsah, Brighi; Zuniga, Floccari, Rizzo
Bologna bench: Da Costa, Stojanovic, Constant, Oikonomou, Ferrari, Krafth, Crisetig, Brienza, Acquafresca