Napoli and Lazio go head-to-head, as only one will emerge with third place and Champions League qualification.
It kicks off at 19.45 UK time (18.45 GMT), follow all the action as it happens on our LIVEBLOG.
The Partenopei need a victory to catch the Aquile in third and would qualify thanks to their superior head-to-head record, as goal difference is irrelevant in Serie A.
Napoli and Lazio go head-to-head, as only one will emerge with third place and Champions League qualification.
It kicks off at 19.45 UK time (18.45 GMT), follow all the action as it happens on our LIVEBLOG.
The Partenopei need a victory to catch the Aquile in third and would qualify thanks to their superior head-to-head record, as goal difference is irrelevant in Serie A.
Lazio were challenging for second until last week’s 2-1 defeat to city rivals Roma, so to drop down to fourth on the final day and lose the Coppa Italia Final to Juventus would be a devastating blow.
Their record at the San Paolo is not good, winning just nine times here with 21 draws and 28 defeats in Serie A.
The most recent victory here was 2-0 in March 2009.
However, Lazio did win the Coppa Italia semi-final 1-0 on April 8, knocking the trophy holders out to the jeers of their home fans.
Miguel Angel Britos sits out a three-match ban after headbutting Juventus striker Alvaro Morata in their 3-1 defeat in Turin.
Jonathan de Guzman, Walter Gargano and Michu are injured, but Gonzalo Higuain leads the attack in potentially his final game in a Napoli jersey.
Pipita is particularly potent in this fixture, as he has scored in each of his last three Serie A meetings with Lazio for a total six goals.
He’s supported by Marek Hamsik, Jose Callejon and Dries Mertens, so Lorenzo Insigne and Manolo Gabbiadini are dropped.
Lazio have Stefan Radu out of action following a hernia operation, while Lucas Biglia and Miroslav Klose had injury concerns leading up to this game.
Neither of them are fit enough to be in the starting XI, so Filip Djordjevic and Danilo Cataldi play instead.
There will be a minute’s silence and Napoli are wearing black armbands after former player and Coach Bruno ‘Petisso’ Pesaola died on Friday.
Napoli: Andujar; Maggio, Albiol, Koulibaly, Ghoulam; David Lopez, Inler; Callejon; Hamsik, Mertens; Higuain
Napoli bench: Rafael, Colombo, Mesto, Strinic, Henrique, Zuniga, Jorginho, Gargano, Gabbiadini, Insigne, Duvan Zapata
Lazio: Marchetti; Mauricio, De Vrij, Gentiletti; Basta, Cataldi, Parolo, Lulic; Candreva, Djordjevic, Felipe Anderson
Lazio bench: Berisha, Strakosha, Novaretti, Braafheid, Cana, Ciani, Biglia, Ledesma, Onazi, Mauri, Perea, Keita, Klose