Andre Silva and Nikola Kalinic lead the Milan attack against Roma trident Edin Dzeko, Alessandro Florenzi and Stephan El Shaarawy.
It kicks off at San Siro at 17.00 UK time (16.00 GMT), follow the build-up and action from all today’s Serie A games on the LIVEBLOG.
This is a huge occasion for Coach Vincenzo Montella, who is under pressure after losing two of his six domestic matches so far this season.
Andre Silva and Nikola Kalinic lead the Milan attack against Roma trident Edin Dzeko, Alessandro Florenzi and Stephan El Shaarawy.
It kicks off at San Siro at 17.00 UK time (16.00 GMT), follow the build-up and action from all today’s Serie A games on the LIVEBLOG.
This is a huge occasion for Coach Vincenzo Montella, who is under pressure after losing two of his six domestic matches so far this season.
With the derby against Inter coming up after the break for international duty, and a hard-fought 3-2 Europa League victory over Rijeka on Thursday, it could be a crossroads in Montella’s San Siro tenure.
Riccardo Montolivo and Davide Calabria are back in the squad after injury, while Hakan Calhanoglu starts following a knock to the back.
The big development is that Andre Silva gets his second Serie A start alongside Kalinic.
The Portugal international has scored six Europa League goals in six games, including the preliminary rounds, but is still looking for his maiden Serie A strike.
Luca Antonelli and Andrea Conti remain on the treatment table.
Roma dropped points only once in Serie A this season, losing 3-1 at home to Inter after rattling the woodwork repeatedly, and this is a big occasion for their Champions League ambitions.
There are injury concerns for Coach Eusebio Di Francesco, missing Diego Perotti, Gregoire Defrel, Patrik Schick, Rick Karsdorp and Emerson Palmieri.
Lorenzo Pellegrini was suffering from flu symptoms, but Florenzi is moved to his old role on the right of a trident attack with Dzeko and ex-Milan star El Shaarawy.
The Giallorossi have won their last three meetings with Milan, but both sides have scored in each of the last four visits to San Siro.
Roma are already on a club record run of nine consecutive away victories.
Milan: G Donnarumma; Musacchio, Bonucci, Romagnoli; Borini, Kessie, Biglia, Calhanoglu, R Rodriguez; Andre Silva, Kalinic
Roma: Alisson; Peres, Fazio, Manolas, Kolarov; Strootman, De Rossi, Nainggolan; Florenzi, Dzeko, El Shaarawy