Lazio and Inter go head-to-head with precious points for Europe at stake, plus Roberto Mancini and Hernanes facing their past.
It kicks off at 19.45 UK time (18.45 GMT), click here for a match preview.
The Stadio Olimpico is of course familiar territory for some of the Inter men, as Mancini was both player and Coach here, while Hernanes was famously in tears when leaving Lazio in January 2014.
Lazio and Inter go head-to-head with precious points for Europe at stake, plus Roberto Mancini and Hernanes facing their past.
It kicks off at 19.45 UK time (18.45 GMT), click here for a match preview.
The Stadio Olimpico is of course familiar territory for some of the Inter men, as Mancini was both player and Coach here, while Hernanes was famously in tears when leaving Lazio in January 2014.
Lazio have the chance to recapture second place from Roma, who were beaten by Inter’s neighbours Milan last night.
Lucas Biglia is back after his injury, but Stefan de Vrij, Lorik Cana, Abdoullay Konko and Senad Lulic are still sidelined.
Felipe Anderson hopes to use his pace against a shaky Inter back four, while Miroslav Klose returns from suspension.
The Nerazzurri miss Zdravko Kuzmanovic, Dodo, Jonathan and Hugo Campagnaro, though Davide Santon returns.
They desperately need points to have any hope of European qualification after a dismal 0-0 home draw with Chievo.
Their history in this fixture isn’t good, losing the last four in a row.
Of course the most famous edition was Lazio 4-2 Inter on May 5 2002, which saw the Nerazzurri lose the Scudetto on the last day of the season.
Lazio: Marchetti; Basta, Mauricio, Ciani, Radu; Biglia, Parolo; Candreva, Mauri, Felipe Anderson; Klose
Lazio bench: Berisha, Strakosha, Braafheid, Djordjevic, Keita, Pereirinha, Gentiletti, Onazi, Ledesma, Cataldi, Perea, Cavanda
Inter: Handanovic; D'Ambrosio, Ranocchia, Vidic, Juan Jesus; Guarin, Medel, Kovacic; Hernanes; Palacio, Icardi
Lazio: Carrizo, Andreolli, Podolski, Santon, Felipe, Gnoukouri, Puscas, Nagatomo, Brozovic, Shaqiri, Dimarco, Bonazzoli