Lazio begin their Serie A campaign against Bologna with Ricardo Kishna and Keita Balde Diao against Mattia Destro.
It kicks off at the Stadio Olimpico at 19.45 UK time (18.45 GMT), click here for a match preview.
This is a special game for the two Coaches, as both Stefano Pioli and Delio Rossi are facing their former clubs.
The Aquile have had a shaky summer, losing five consecutive friendlies and falling 2-0 to Juventus in the Italian Super Cup.
Lazio begin their Serie A campaign against Bologna with Ricardo Kishna and Keita Balde Diao against Mattia Destro.
It kicks off at the Stadio Olimpico at 19.45 UK time (18.45 GMT), click here for a match preview.
This is a special game for the two Coaches, as both Stefano Pioli and Delio Rossi are facing their former clubs.
The Aquile have had a shaky summer, losing five consecutive friendlies and falling 2-0 to Juventus in the Italian Super Cup.
They got back on track by beating Bayer Leverkusen 1-0 with a Keita strike in the Champions League play-off.
Miroslav Klose, Filip Djordjevic and Federico Marchetti are out injured, so Keita starts with Candreva and new signing Kishna.
Stefan de Vrij is available after being stretchered off against Bayer Leverkusen with a knock to the head.
Stefano Mauri is on the bench just hours after signing a new contract, having been released on June 30.
Franco Zuculini, Daniele Gastaldello and Luca Rizzo are sidelined with Ibrahima Mbaye suspended.
Destro was expected to make his debut in a Bologna jersey just days after the loan with option to buy from Roma was completed.
However, he’s on the bench in favour of Franco Brienza, Robert Acquafresca and former Serie B star Matteo Mancosu.
Lazio: Berisha; Basta, De Vrij, Gentiletti, Radu; Parolo, Biglia, Lulic; Candreva, Keita, Kishna
Lazio bench: Guerrieri, Konko, Mauricio, Hoedt, Patric, Braafheid, Morrison, Cataldi, Onazi, Milinkovic-Savic, Mauri, Felipe Anderson
Bologna: Mirante; Ferrari, Rossettini, Oikonomou, Masina; Crimi, Crisetig, Brighi; Brienza; Acquafresca, Mancosu
Bologna bench: Da Costa, Stojanovic, Maietta, Ceccarelli, Morleo, Pulgar, Diawara, Silvestro, Falco, Destro