Juventus are forced to revamp their defence again with Merih Demiral, while Sassuolo must do without Domenico Berardi.
It kicks off in Turin at 19.45 GMT, you can follow the build-up and action as it happens on the LIVEBLOG.
The Bianconeri have a huge opportunity to climb up into fourth place, one point behind Roma with a game in hand.
Juventus are forced to revamp their defence again with Merih Demiral, while Sassuolo must do without Domenico Berardi.
It kicks off in Turin at 19.45 GMT, you can follow the build-up and action as it happens on the LIVEBLOG.
The Bianconeri have a huge opportunity to climb up into fourth place, one point behind Roma with a game in hand.
Their enthusiasm is sky high after beating leaders Milan 3-1 at San Siro on Wednesday evening, despite missing Alex Sandro and Juan Cuadrado with COVID-19.
Matthijs de Ligt also tested positive yesterday, so the options in defence are very limited and Merih Demiral gets a rare start with Gianluca Frabotta.
Federico Chiesa and Weston McKennie take the wings, with Paulo Dybala and Cristiano Ronaldo upfront, as Alvaro Morata is still only fit for the bench.
Sassuolo have problems too, as captain Berardi is out injured along with Filippo Romagna and Federico Ricci.
Hamed Junior Traore, Filip Djuricic and Gregoire Defrel therefore fan out behind Francesco Caputo, leaving Jeremie Boga on the bench.
Pedro Obiang gets the nod rather than Maxime Lopez or Medhi Bourabia in midfield alongside Juve transfer target Manuel Locatelli.
Juventus: Szczesny; Danilo, Bonucci, Demiral, Frabotta; Chiesa, Bentancur, Arthur, McKennie; Dybala, Ronaldo
Juventus bench: To follow
Sassuolo: Consigli; Muldur, Chiriches, Ferrari, Kyriakopoulos; Obiang, Locatelli; Defrel, Djuricic, Traore; Caputo
Sassuolo bench: Pegolo, Marlon, Magnanelli, Ayhan, Rogerio, Boga, Lopez, Peluso, Raspadori, Toljan, Oddei, Schiappacasse
Ref: Massa