Leaders Juventus host fourth-placed Sampdoria in the early game, a fixture that traditionally has plenty of goals.
It kicks off at 11.30 GMT, click here for a match preview.
Both these sides have suffered only one defeat in Serie A all season, so this is an extremely tough test for the Old Lady.
Samp have been one of the surprise packages this term and were sitting pretty in fourth place going into this weekend, ahead of Napoli, Milan, Fiorentina and Inter.
Leaders Juventus host fourth-placed Sampdoria in the early game, a fixture that traditionally has plenty of goals.
It kicks off at 11.30 GMT, click here for a match preview.
Both these sides have suffered only one defeat in Serie A all season, so this is an extremely tough test for the Old Lady.
Samp have been one of the surprise packages this term and were sitting pretty in fourth place going into this weekend, ahead of Napoli, Milan, Fiorentina and Inter.
However, Juve’s problems with the Blucerchiati stretch back to January 6 2013, as that 2-1 result was the last time the hosts lost at the Juventus Stadium.
That was followed by 32 wins and two draws with 82 goals scored and 15 conceded.
The last five meetings between these sides have been spectacular with 23 goals overall, an average of 4.6 per match, including last season’s 4-2 thriller.
Having said that, Juventus have drawn their last two games 0-0 against Fiorentina and Atletico Madrid.
Stephan Lichtsteiner returns from suspension, but Giorgio Chiellini now sits out a ban with the injured Marco Storari, Kwadwo Asamoah, Martin Caceres, Andrea Barzagli, Luca Marrone and Romulo.
Angelo Ogbonna therefore steps into the back four, with Alvaro Morata given a rare start in attack alongside Carlos Tevez.
Andrea Pirlo is rested, as Claudio Marchisio returns after missing Atletico Madrid with flu symptoms.
Sampdoria have Lorenzo De Silvestri suspended, Matias Silvestre, Gianluca Sansone and Pawel Wszolek sidelined.
On the verge of a move to Napoli, Manolo Gabbiadini is again dropped to the bench in favour of Nenad Krsticic in a trequartista role behind Stefano Okaka and Eder. That means Roberto Soriano is also benched, as he's suffering from a fever.
Coach Sinisa Mihajlovic said in his Press conference that Samp would be ‘The Good, The Bad and The Ugly’ in this match. He quoted a character in that spaghetti western classic stating he preferred to knock down the ‘big’ opponents, as they make more noise when they fall.
Juventus: Buffon; Lichtsteiner, Bonucci, Ogbonna, Evra; Vidal, Marchisio, Pogba; Pereyra; Tevez, Morata
Juventus bench: Rubinho, Audero, Pepe, Padoin, Pirlo, Mattiello, Coman, Giovinco, Llorente
Sampdoria: Romero; Cacciatore, Gastaldello, Romagnoli, Regini; Rizzo, Palombo, Obiang; Krsticic; Okaka, Eder
Sampdoria bench: Da Costa, Mesbah, Duncan, Fedato, Gabbiadini, Soriano, Djordjevic, Marchionni, Fornasier