Juventus start Miralem Pjanic, Mario Mandzukic and Gonzalo Higuain as they host second-placed Roma with Gerson and Edin Dzeko.
It kicks off at the Juventus Stadium at 19.45 GMT, follow the build-up and action on the Liveblog.
This is a Scudetto showdown in Turin, as only four points separate leaders Juve from Roma, who consolidated second by beating Milan 1-0 on Monday night.
Juventus start Miralem Pjanic, Mario Mandzukic and Gonzalo Higuain as they host second-placed Roma with Gerson and Edin Dzeko.
It kicks off at the Juventus Stadium at 19.45 GMT, follow the build-up and action on the Liveblog.
This is a Scudetto showdown in Turin, as only four points separate leaders Juve from Roma, who consolidated second by beating Milan 1-0 on Monday night.
The Bianconeri are without Leonardo Bonucci and Dani Alves, but Andrea Barzagli is back on the bench after dislocating his shoulder, recovering much quicker than expected.
Paulo Dybala is not risked from the start, despite coming on to turn their 3-1 Derby della Mole victory over Torino last week.
Instead, Pjanic faces his former Roma teammates for the first time, supporting Higuain and Mandzukic.
Stefano Sturaro is the pick for a rugged midfield, while there was uncertainty to the end between Daniele Rugani and Medhi Benatia.
Roma have issues too, as Francesco Totti, Alessandro Florenzi and Leandro Paredes miss out.
Mohamed Salah was expected to start after a late fitness test, but instead Brazilian trequartista Gerson is given a rare chance to shine.
Dzeko remains joint Capocannoniere with Mauro Icardi and leads the way with support from Radja Nainggolan and Diego Perotti.
It’s safe to say Roma do not have a good history in Turin, losing their last five Serie A trips and managing just one point here since their 2-1 victory in January 2010.
In that period they scored four goals and conceded 16.
Juventus: Buffon; Lichtsteiner, Rugani, Chiellini, Alex Sandro; Khedira, Marchisio, Sturaro; Pjanic; Mandzukic, Higuain
Juventus bench: Neto, Audero, Barzagli, Benatia, Evra, Mattiello, Cuadrado, Hernanes, Lemina, Asamoah, Dybala, Pjaca
Roma: Szczesny; Rudiger, Manolas, Fazio, Emerson Palmieri; De Rossi, Strootman; Gerson, Nainggolan, Perotti; Dzeko
Roma bench: Alisson, Romagnoli, Juan Jesus, Bruno Peres, Vermaelen, Seck, Mario Rui, Salah, Iturbe, El Shaarawy