Juventus must do without Gigi Buffon, Leonardo Bonucci and Alex Sandro, but start Paulo Dybala as they host Bologna.
It kicks off in Turin at 19.45 GMT, follow the build-up and action on our Liveblog.
The Bianconeri ended 2016 with disappointment, as Milan beat them in a Doha penalty shoot-out to win the Supercoppa Italiana.
Juventus must do without Gigi Buffon, Leonardo Bonucci and Alex Sandro, but start Paulo Dybala as they host Bologna.
It kicks off in Turin at 19.45 GMT, follow the build-up and action on our Liveblog.
The Bianconeri ended 2016 with disappointment, as Milan beat them in a Doha penalty shoot-out to win the Supercoppa Italiana.
They’re now feeling the pressure at the top of Serie A too, after Roma and Napoli successes, but have the opportunity to make history.
A win here would set a new all-time record of 26 consecutive Serie A home victories.
Max Allegri is without captain Buffon, who is nursing a cold, joined by injured Leo Bonucci, Alex Sandro and Dani Alves.
Medhi Benatia and Mario Lemina are on Africa Cup of Nations duty, with new signing Tomas Rincon on the bench just days after his arrival from Genoa.
Miralem Pjanic takes a trequartista role behind Dybala, returning to the start after six weeks, and Gonzalo Higuain.
Patrice Evra was left out of the squad, as he is considering offers from Valencia and Manchester United.
Bologna are still without Umar Sadiq and Simone Verdi, but full-back Adam Masina has been linked with a move to Juve as Evra’s replacement.
Federico Di Francesco, Mattia Destro and impressive Ladislav Krejci form the trident attack.
The Rossoblu haven’t beaten Juventus, home or away, since a 2-0 Turin triumph in February 2011, losing five and drawing three.
Juventus: Neto; Lichtsteiner, Barzagli, Chiellini, Asamoah; Khedira, Marchisio, Sturaro; Pjanic; Dybala, Higuain
Bologna: Mirante; Torosidis, Oikonomou, Maietta, Masina; Donsah, Viviani, Dzemaili; Krejci, Destro, Di Francesco