Fiorentina start Alberto Gilardino against Mattia Destro, as Milan try to end their crisis at the Stadio Franchi.
It kicks off at 18.00 GMT, click here to follow the action from this game and Torino v Lazio on our LIVEBLOG.
The Viola need a boost after a 4-0 defeat to Lazio and 1-1 home Europa League draw with Roma, but a win would take them within a point of fourth place.
Fiorentina start Alberto Gilardino against Mattia Destro, as Milan try to end their crisis at the Stadio Franchi.
It kicks off at 18.00 GMT, click here to follow the action from this game and Torino v Lazio on our LIVEBLOG.
The Viola need a boost after a 4-0 defeat to Lazio and 1-1 home Europa League draw with Roma, but a win would take them within a point of fourth place.
Vincenzo Montella, who has been heavily linked with the Milan job for next season, as usual must deal with injury problems.
Nenad Tomovic is suspended with David Pizarro, Mario Gomez, Stefan Savic, Ciprian Tatarusanu, Giuseppe Rossi and Federico Bernardeschi sidelined.
Gilardino gets his first start since arriving from Guangzhou Evergrande in January and he is supported by Josip Ilicic and Borja Valero.
Milan have a huge absentee list too, as Andrea Poli picked up a one-match ban, joining injured Mattia De Sciglio, Nigel de Jong, Riccardo Montolivo, Cristian Zapata, Stephan El Shaarawy, Pablo Armero, Hachim Mastour and Adil Rami.
Having been dropped in favour of Giampaolo Pazzini in the 2-2 draw with Verona, Mattia Destro returns to partner Jeremy Menez.
Keisuke Honda gets a rare start in a supporting midfield role, possibly as a trequartista.
Milan are unbeaten at the Stadio Franchi since November 2005, picking up five wins and three draws.
Fiorentina haven’t kept a clean sheet in their last five Serie A home fixtures.
Fiorentina: Neto; Richards, Gonzalo Rodriguez, Basanta; Rosi, Borja Valero, Kurtic, Aquilani, Pasqual; Ilicic, Gilardino
Fiorentina bench: Rosati, Lezzerini, Marcos Alonso, Babacar, Vargas, Diamanti, Badelj, Lazzari, Joaquin, Mati Fernandez, Salah
Milan: Diego Lopez; Abate, Paletta, Mexes, Antonelli; Essien, Van Ginkel, Bonaventura; Honda; Menez, Destro
Milan bench: Abbiati, Gori, Muntari, Suso, Pazzini, Albertazzi, Boccchetti, Cerci, Bonera, Alex, Mastalli, Locatelli