Lazio have the chance to go clear in third place, but face a tricky trip to unpredictable Torino.
It kicks off at 18.00 GMT, click here to follow on our LIVEBLOG along with Fiorentina v Milan.
The Aquile are now the form team in Serie A after four consecutive victories allowed them to catch Napoli in joint third.
As Rafa Benitez’s men were beaten 2-0 by Verona on Sunday, Lazio can go clear in third and even close in on city rivals Roma.
Lazio have the chance to go clear in third place, but face a tricky trip to unpredictable Torino.
It kicks off at 18.00 GMT, click here to follow on our LIVEBLOG along with Fiorentina v Milan.
The Aquile are now the form team in Serie A after four consecutive victories allowed them to catch Napoli in joint third.
As Rafa Benitez’s men were beaten 2-0 by Verona on Sunday, Lazio can go clear in third and even close in on city rivals Roma.
Toro were unbeaten in 13 competitive games before their downturn in fortunes, suffering defeats to Udinese and Zenit.
There is the real risk of fatigue after Thursday’s 2-0 loss in Russia and Giampiero Ventura has to keep his side fresh for the second leg.
Giuseppe Vives, Alessandro Gazzi, Salvatore Masiello and Cristian Molinaro miss out for the hosts, while Josef Martinez and Amauri start in attack.
Lazio have Antonio Candreva suspended, plus Bruno Pereirinha, Santiago Gentiletti and Filip Djordjevic injured.
Felipe Anderson is the one to watch, completing a trident attack with Miroslav Klose and Stefano Mauri.
Senad Lulic is back in the squad after two months out with a knee ligament injury.
Torino: Padelli; Maksimovic, Jansson, Bovo; Bruno Peres, Benassi, Basha, El Kaddouri, Gabriel Silva; Amauri, Martinez
Torino bench: Castellazzi, Ichazo, Glik, Moretti, Alvaro Gonzalez, Quagliarella, Maxi Lopez
Lazio: Marchetti; Basta, De Vrij, Mauricio, Radu; Cataldi, Biglia, Parolo; Felipe Anderson, Klose, Mauri
Lazio bench: Berisha, Strakosha, Novaretti, Braafheid, Cavanda, Ciani, Ederson, Lulic, Ledesma, Onazi, Keita, Perea