Gonzalo Higuain is hoping to break his Milan duck and Cagliari welcome back Joao Pedro from his doping ban.
It kicks off at the Sardegna Arena at 19.30 UK time (18.30 GMT).
Follow the build-up and action as it happens on the LIVEBLOG.
Gennaro Gattuso maintains the same starting XI that beat Roma before the break for international duty.
Gonzalo Higuain is hoping to break his Milan duck and Cagliari welcome back Joao Pedro from his doping ban.
It kicks off at the Sardegna Arena at 19.30 UK time (18.30 GMT).
Follow the build-up and action as it happens on the LIVEBLOG.
Gennaro Gattuso maintains the same starting XI that beat Roma before the break for international duty.
Andrea Conti and Ivan Strinic are still injured, joined on the treatment table by super-sub Patrick Cutrone after he sprained his ankle playing for the Italy Under-21 side.
Higuain is hoping to get his first goal in a Milan jersey and is flanked by Suso and Hakan Calhanoglu, with Jack Bonaventura in midfield.
Cagliari miss Luca Ceppitelli and ex-Rossoneri goalkeeper Rafael, but Ragnar Klavan is able to start despite some fatigue from international duty.
Bradaric is chosen rather than Luca Cigarini in midfield, but the big change is the return of Joao Pedro, who has been banned since March for failing a doping test.
He supports Leonardo Pavoletti and Diego Farias.
Cagliari: Cragno; Srna, Klavan, Romagna, Padoin; Castro, Bradaric, Barella; Joao Pedro; Farias, Pavoletti
Cagliari bench: Aresti, Daga, Andreolli, Lykogiannis, Pisacane, Pajac, Cigarini, Dessena, Faragò, Ionita, Cerri, Sau
Milan: G Donnarumma; Calabria, Musacchio, Romagnoli, Rodriguez; Kessie, Biglia, Bonaventura; Suso, Higuain, Calhanoglu
Milan bench: Reina, A Donnarumma, Abate, Caldara, Laxalt, Zapata, Bakayoko, Bertolacci, Mauri, Borini, Castillejo, Tsadjout
Ref: Abisso