Juventus are expected to go 4-3-3 with Douglas Costa, Mario Mandzukic and Gonzalo Higuain, but Real Madrid have doubts in defence.
The Champions League quarter-final kicks off at 19.45 UK time (18.45 GMT) after a shock 3-0 home defeat in the first leg.
Paulo Dybala and Rodrigo Bentancur are suspended, with Andrea Barzagli and Federico Bernardeschi injured, but Miralem Pjanic and Medhi Benatia return from suspension.
Max Allegri is believed to be using a 4-3-3 formation with Higuain flanked by Douglas Costa and Mandzukic rather than Juan Cuadrado.
Juventus are expected to go 4-3-3 with Douglas Costa, Mario Mandzukic and Gonzalo Higuain, but Real Madrid have doubts in defence.
The Champions League quarter-final kicks off at 19.45 UK time (18.45 GMT) after a shock 3-0 home defeat in the first leg.
Paulo Dybala and Rodrigo Bentancur are suspended, with Andrea Barzagli and Federico Bernardeschi injured, but Miralem Pjanic and Medhi Benatia return from suspension.
Max Allegri is believed to be using a 4-3-3 formation with Higuain flanked by Douglas Costa and Mandzukic rather than Juan Cuadrado.
Alex Sandro can therefore return to his old left-back role with Mattia De Sciglio on the right.
Blaise Matuidi was dropped for the first leg, but the former Paris Saint-Germain star brings some valuable experience to midfield.
Real Madrid must do without suspended Sergio Ramos, while Nacho Monreal is injured and Lucas Vazquez is in doubt with an ankle issue.
The real problem for Zinedine Zidane is at centre-back to replace Ramos, as he has two main options.
The first would be to start 21-year-old Jesus Vallejo, who has only four Liga appearances this season and has never played in the Champions League.
He only recently recovered from a thigh injury too and played just once in 2018, a 3-0 victory away to Las Palmas on March 31.
Another alternative would be moving Casemiro to centre-back, therefore introducing ex-Inter man Mateo Kovacic to midfield.
Isco supporting Cristiano Ronaldo and Karim Benzema seems inevitable, with again no sign of Gareth Bale.
Probable line-ups
Real Madrid: Navas; Carvajal, Casemiro, Varane, Marcelo; Kovacic, Kroos, Modric; Isco; Cristiano Ronaldo, Benzema
Juventus: Buffon; De Sciglio, Benatia, Chiellini, Alex Sandro; Khedira, Pjanic, Matuidi; Douglas Costa, Higuain, Mandzukic