Sampdoria coach Dejan Stankovic was visibly moved as the Inter fans gave him a standing ovation at the Stadio Giuseppe Meazza.
It kicks off at San Siro at 19.45 UK time (18.45 GMT).
You can follow all the build-up and action as it happens on the LIVEBLOG.
This is an emotional night for Stankovic, who was part of the squad that won the Treble in 2010 under Jose Mourinho.
He stepped into San Siro for the first time as an opposition coach, having taken over at Sampdoria this month, and was given a warm welcome.
The Serbian was visibly moved and applauded in return to the fans who gave him a standing ovation during the warm-up.
Ultras also put up a banner that read: ‘Yesterday, today and for always, Dejan is one of us.’