Spezia are expected to be without midfielder Mehdi Bourabia for around two months after he was diagnosed with a serious calf strain.
There are numerous problems for coach Thiago Motta to deal with, as he is already missing Omar Colley, Leo Sena, Kevin Agudelo and Arkadiusz Reca for several weeks.
Bourabia was diagnosed with a distractive lesion to the calf muscle in the right leg.
Simone Bastoni is also absent for the next two games after he was given a two-match Serie A ban.
Bourabia is on loan with obligation to buy from Sassuolo and already scored one goal in his four Serie A appearances for Spezia this season.