Roma are again forced into changes, losing yet more key players for this trip to Spezia, as Nicolò Zaniolo is only on the bench and teenager Nicola Zalewski starts.
It kicks off at the Stadio Picco at 17.05 GMT.
Serie A Liveblog: Torino-Cagliari, Verona-Venezia, Spezia-Roma, Lazio-Napoli
Jose Mourinho is struggling with three straight stalemates in Serie A and has numerous selection problems going into this game.
January signing Sergio Oliveira and teenage striker Felix Afena-Gyan didn’t make the trip due to muscular problems, while Zaniolo is not fit enough to start either.
That means Henrikh Mkhitaryan is rushed back into the starting XI with Lorenzo Pellegrini to support Tammy Abraham, with Jordan Veretout in midfield.
Teenage Poland international Nicola Zalewski gets his first Serie A start.
Roger Ibanez, Carles Perez and Eldor Shomurodov are available again, but not 100 per cent fit, while Gianluca Mancini is back from suspension.
Spezia have Kelvin Amian in the side after his ban expired, but he is replaced on the naughty step by striker Rey Manaj.
Spezia: Provedel; Amian, Erlic, Nikolaou, Reca; Kiwior, Sala, S Bastoni; Agudelo, Verde; Nzola
Roma: Rui Patricio; Mancini, Smalling, Kumbulla; Karsdorp, Cristante, Veretout, Zalweski; Mkhitaryan, Pellegrini; Abraham