Milan try to consolidate their Serie A leadership with Rafael Leao, Theo Hernandez and Olivier Giroud, while Salernitana debut under new coach Davide Nicola with Franck Ribery.
It kicks off at the Stadio Arechi at 19.45 GMT.
Serie A Liveblog: Sampdoria-Empoli, Roma-Verona, Salernitana-Milan
Stadium capacity was upgraded from 50 per cent to 75 per cent this morning, so Salernitana rushed to put extra tickets on sale just hours before the match.
They are making their debut under new coach Nicola, becoming their third boss of the season, as Stefano Colantuono was sacked this week.
Salernitana are rock bottom, but they also have two games in hand to be played against Udinese and Venezia after winning their appeals amid COVID outbreaks.
Simone Verdi, Norbert Gyomber, Di Tacchio, Mamadou Coulibaly and Schiavone are injured, while several new players were drafted in during the January transfer window.
Ederson pulls the midfield strings with Franck Ribery supporting Milan Djuric and Federico Bonazzoli.
Nicola famously achieved miracles to keep Crotone and Genoa in Serie A, so could he do the same for Salernitana?
Milan are top of the table, still missing Zlatan Ibrahimovic and Simon Kjaer, so Giroud must continue to lead the attack.
Theo Hernandez returns after suspension, with Franck Kessie again sent to the bench in favour of Sandro Tonali and Ismael Bennacer.
Junior Messias, Brahim Diaz and Rafael Leao fan out in support of the centre-forward.
Salernitana: Sepe; Mazzocchi, Dragusin, Fazio, Ranieri; L Coulibaly, Radovanovic, Kastanos; Ribery; Djuric, Bonazzoli
Milan: Maignan; Calabria, Tomori, Romagnoli, Theo Hernandez; Tonali, Bennacer; Messias, Brahim Diaz, Leao; Giroud