Roma bring Lorenzo Pellegrini back into midfield, with Tammy Abraham and Nicolò Zaniolo upfront against Andrea Belotti’s Torino.
It kicks off at the Stadio Olimpico in Rome at 17.00 GMT.
The Giallorossi are stretched thin at the moment between Serie A and the Europa Conference League, as Bryan Cristante and Gonzalo Villar are still self-isolating after testing positive for COVID-19.
Jordan Veretout is also suspended, with Leonardo Spinazzola injured and Matias Vina not at 100 per cent.
Pellegrini therefore returns and is pushed into a deeper midfield role, with Jose Mourinho still backing the three-man defence.
Torino have won their last three home games and lost three in a row on their travels.
They are without Cristian Ansaldi, Simone Verdi, Ricardo Rodriguez, Rolando Mandragora and Simone Edera.
Belotti leads the attack with support from Dennis Praet and Josip Brekalo.
Roma: Rui Patricio; Mancini, Smalling, Ibanez; Karsdorp, Pellegrini, Diawara, Mkhitaryan, El Shaarawy; Abraham, Zaniolo
Torino: Milinkovic-Savic; Djidji, Bremer, Buongiorno; Singo, Lukic, Pobega, Vojvoda; Praet, Brekalo; Belotti