Juventus revamp their tactics with Paulo Dybala, Dusan Vlahovic and Alvaro Morata together, while Inter welcome Marcelo Brozovic back behind Edin Dzeko and Lautaro Martinez.
It kicks off at 19.45 UK time (18.45 GMT) at the Allianz Juventus Stadium in Turin.
You can follow all the build-up and action as it happens on the LIVEBLOG.
This is not only the Derby d’Italia, but also a head-to-head for third place, which could keep Juve in the Scudetto race or rule Inter out of it.
Luca Pellegrini is suspended, with Federico Chiesa, Weston McKennie, Kaio Jorge and Marley Ake injured.
Denis Zakaria is back after a month out, but it’s Adrien Rabiot who allows Max Allegri a change of tactics to 4-2-3-1, using Juan Cuadrado, Dybala, Morata and Vlahovic together.
Inter get Marcelo Brozovic back from a calf injury, having struggled in the two games without their midfield dynamo.
Stefan de Vrij also returns on the bench, as Lautaro Martinez and Dzeko lead the way.
Juventus: Szczesny; Danilo, De Ligt, Chiellini, Alex Sandro; Locatelli, Rabiot; Cuadrado, Dybala, Morata; Vlahovic
Inter: Handanovic; D’Ambrosio, Skriniar, Bastoni; Dumfries, Barella, Brozovic, Calhanoglu, Perisic; Lautaro Martinez, Dzeko