Simone Inzaghi faces his former club without suspended Hakan Calhanoglu, while Ciro Immobile and Sergej Milinkovic-Savic start for Maurizio Sarri’s Lazio.
It kicks off at San Siro at 19.45 GMT, you can follow all the build-up and action as it happens from today’s Serie A games on the LIVEBLOG.
The Nerazzurri need a win to retake top spot from Milan, even though they do have two games in hand including this one.
Because their match with Bologna was called off on Thursday due to a COVID outbreak in the Rossoblu squad, it means Calhanoglu has not completed his ban and is therefore suspended here instead.
Edin Dzeko has shaken off COVID-19 and is on the bench, so Roberto Gagliardini starts with Alexis Sanchez and Lautaro Martinez.
Lazio are fresh from a 3-3 thriller with Empoli, as Sarri continues to struggle getting his football to work with a team built for Simone Inzaghi’s 3-5-2.
Francesco Acerbi is injured and Jean-Daniel Akpa-Akpro at the Africa Cup of Nations.
Milinkovic-Savic leads the midfield with Danilo Cataldi and Toma Basic, benching Luis Alberto.
Felipe Anderson and Pedro again flank Ciro Immobile.
Inter: Handanovic; Skriniar, De Vrij, Bastoni; Dumfries, Barella, Brozovic, Gagliardini, Perisic; Alexis Sanchez, Lautaro Martinez
Lazio: Strakosha; Hysaj, Luiz Felipe, Radu, Marusic; Milinkovic-Savic, Cataldi, Basic; Felipe Anderson, Immobile, Pedro
Pairetto, what a dramatic first half of refereeing.